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KMID : 0858520130170030207
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Journal of the Korean Society of Magnetic Resonance in Medicine
2013 Volume.17 No. 3 p.207 ~ p.214
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Magnetic Resonance Imaging of Breast Cancer Patients with BRCA Mutation
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Chung Sun-Young
Cha Joo-Hee
Kim Hak-Hee
Shin Hee-Jung
Kim Hyun-Ji
Chae Eun-Young
Shin Ji-Eun
Choi Woo-Jung
Hong Min-Ji
An Sei-Hyun
Lee Jong-Won
Jung Kyung Hae
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Abstract
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Purpose: To evaluate the MRI findings of breast cancer with BRCA mutation.
Materials and Methods: We collected information of the breast cancer patients who underwent the test for BRCA gene mutation as well as preoperative breast MRI from January 2007 to December 2010. A total of 185 patients were enrolled; 33 of these patients had BRCA mutations and 152 patients did not. Among them, a total of 231 breast cancers were detected. Images of the 47 breast cancers with BRCA mutation and of the 184 breast cancers without mutations were evaluated to compare the morphologic and enhancement features on MRI.
Results: With MR imaging, there were no significant difference in morphologic characteristic between two groups. However, enhancement pattern in the group with BRCA mutation were more likely to have persistent enhancement (p < 0.233), and LN metastasis was more common in breast cancers without BRCA mutation. Breast cancers with BRCA 2 mutation tend to show more persistent enhancement pattern than BRCA 1 mutation.
Conclusion: In breast cancer patients with BRCA mutation, MRI didn't show significant difference in morphologic characteristics, however breast cancers with BRCA gene mutation carriers tend to have benign morphologic features on MRI, such as Type 1 kinetic curve enhancement.
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KEYWORD
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BRCA mutation, Breast cancer, Magnetic resonance imaging (MRI)
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